What is the place of Fractionated Exhaled Nitric Oxide in the diagnosis and monitoring of pediatric asthma in 2023?

Abstract

Fractional exhaled nitroc oxide (FeNO) measurement is a patial and indirect estimate of eosinophilic bronchial infllammation. It can be performed in a reproducible, convenient and rapid manner from the age of 5 to 6 years. The FeNO measurement methodology has been validated by a European Respiratory Society / American Thoracic Society consensus. The American Thoracic Society, the National Institute for Health and Care Excellence and the European Respiratory Society have published recommendations with cut-off values for FeNO to guide the diagnosis, treatment and follow-up of asthma in children aged 5-16 years. Internationally validated percentile curves of FeNO values according to height, will allow us to interpret the FeNO value of the child and adolescent in a more statistically relevant way and to have a more accurate tool for diagnosis, phenotyping and follow-up.