Caudal regression syndrome: 2 Case reports and literature review

Abstract

Caudal regression syndrome (CRS) is a rare congenital disorder in which there is abnormal fetal development of the caudal partition of the spine. CRS has a broad clinical spectrum with variable anomalies of the lumbosacral spine, lower limbs, anorectal complex and genitourinary tract. Patients present with a variety of symptoms or features. We report two clinical cases, describing the clinical manifestations and diagnosis of these patients. We discuss the importance of screening for additional anomalies, early intervention and multidisciplinary follow-up.