Optimizing diagnosis in drug hypersensitivity: PhD thesis presented on 27/1/2023 at the University of Antwerp, Antwerp, Belgium

Abstract

Drug hypersensitivity reactions constitute an important and increasing health problem with significant morbidity and mortality, associated with both over- and underdiagnosis.

Given the dramatic impact of mislabelling, correct diagnosis is of utmost importance. However, this is not always straightforward, since the available diagnostic tests each carry their own limitations.

Hence this thesis, which aimed to optimize the diagnosis of drug hypersensitivity. In a first objective, the cut-off of specific IgE quantification and potential of a specific-to-total IgE ratio was investigated. Next, we looked at the non-irritant concentrations of skin tests. In the third objective, we objectified the need for drug provocation tests with anaesthetic drugs. Finally, the optimal timing of testing was investigated.